PARIS, FRANCE, April 5, 2025 –Dr. Luca Villa, Senior Clinical Scientist, presented our work focused on using QyScore® and QyPredict® to differentiate patients with progressive supranuclear palsy from patients with Parkinson’s disease.
The presentation, titled “𝘘𝘺𝘚𝘤𝘰𝘳𝘦® 𝘢𝘯𝘥 𝘘𝘺𝘗𝘳𝘦𝘥𝘪𝘤𝘵®: 𝘏𝘰𝘸 𝘧𝘶𝘭𝘭𝘺-𝘢𝘶𝘵𝘰𝘮𝘢𝘵𝘦𝘥 𝘪𝘮𝘢𝘨𝘪𝘯𝘨 𝘢𝘯𝘥 𝘮𝘢𝘤𝘩𝘪𝘯𝘦 𝘭𝘦𝘢𝘳𝘯𝘪𝘯𝘨 𝘮𝘦𝘵𝘩𝘰𝘥𝘴 𝘤𝘢𝘯 𝘴𝘶𝘱𝘱𝘰𝘳𝘵 𝘥𝘪𝘧𝘧𝘦𝘳𝘦𝘯𝘵𝘪𝘢𝘵𝘪𝘰𝘯 𝘰𝘧 𝘗𝘢𝘳𝘬𝘪𝘯𝘴𝘰𝘯’𝘴 𝘋𝘪𝘴𝘦𝘢𝘴𝘦 𝘢𝘯𝘥 𝘗𝘳𝘰𝘨𝘳𝘦𝘴𝘴𝘪𝘷𝘦 𝘚𝘶𝘱𝘳𝘢𝘯𝘶𝘤𝘭𝘦𝘢𝘳 𝘗𝘢𝘭𝘴𝘺”, focused on the key topic of trying to distinguish Parkinson’s disease from progressive supranuclear palsy, using fully-automated QyScore® markers and advanced machine learning algorithms from QyPredict®.
Around 50% of patients with progressive supranuclear palsy are initially misdiagnosed as having Parkinson’s disease, due to both conditions having similar clinical presentations. Given this substantial clinical problem, we investigated whether QyPredict®’s advanced machine learning algorithms, would be able to accurately differentiate these two patient groups based on QyScore®’s fully-automated MRI markers. Through this combination of QyScore® and QyPredict®, we were able to achieve excellent performances, accurately differentiating between progressive supranuclear palsy and Parkinson’s disease, with a balanced accuracy of 92%, a sensitivity of 87%, and a specificity of 97%.
This study demonstrated the exciting potential for the use of this approach in future clinical routine, to aid clinicians in the difficult and time-consuming task of differentiating progressive supranuclear palsy from Parkinson’s disease.
We would like to thank our brilliant team who worked on the project, including our collaborators at the Universities of Verona and Salerno, and look forward to developing the project further.
About Qynapse: Qynapse SAS is a medical technology company commercializing an AI-powered and proprietary neuroimaging software platform, creating the potential for earlier clinical precision on the frontlines of CNS disease. Qynapse’s flagship solution, QyScore®, FDA-Cleared and CE-Marked, adds the potential for more precise and objective brain scan analysis. Qynapse is headquartered in France with offices in the US Canada. www.qynapse.com