PARIS, FRANCE, May 6, 2025 – We are thrilled to share that Qynapse’s collaborative study with Amsterdam UMC has been published in Alzheimer’s Research & Therapy: “Clinical phenotypes of Alzheimer’s disease: investigating atrophy patterns and their pathological correlates”
https://alzres.biomedcentral.com/articles/10.1186/s13195-025-01727-5
This groundbreaking research leverages QyScore®’s neuroimaging technology to analyze post-mortem and ante-mortem MRI data, linking structural brain atrophy with key Alzheimer’s disease (AD) pathologies, including amyloid-beta, pTau, neurofilament light (NfL), and vascular deterioration markers (COLIV) across both typical and atypical AD phenotypes.
Key findings from the study include:
- Posterior cingulate volume was lower in typical Alzheimer’s disease compared to atypical Alzheimer’s disease.
- Differences in volume-pathology relationships between clinical phenotypes were region-specific.
- Cortical volume was affected by amyloid-beta and neuro-axonal damage, but in opposing directions for the phenotypes.
- Post-mortem and ante-mortem scans showed minimal volume differences, at scan intervals of 2-years, demonstrating the translational capability of the work.
It has been a true privilege to work alongside the outstanding team at Amsterdam UMC (https://lnkd.in/e4MhyrmG) and the excellent co-authors Niels Reijner, Irene Frigerio, Maud Bouwman, Baayla Dimitri Catharina Achternaam Boon, Nicolas Guizard, Thomas Jubault, PhD, MBA, Jeroen Hoozemans, Annemieke Rozemuller-Kwakkel, Femke Bouwman,
Frederik Barkhof, Elizabeth Gordon, Wilma Van de Berg, Laura Jonkman.
About Qynapse: Qynapse SAS is a medical technology company commercializing an AI-powered and proprietary neuroimaging software platform, creating the potential for earlier clinical precision on the frontlines of CNS disease. Qynapse’s flagship solution, QyScore®, FDA-Cleared and CE-Marked, adds the potential for more precise and objective brain scan analysis. Qynapse is headquartered in France with offices in the US Canada.
www.qynapse.com